NISOLDIPINE (BAY-K-5552), A NEW CALCIUM-ANTAGONIST - ANTIHYPERTENSIVE EFFECT IN CONSCIOUS, UNRESTRAINED RENAL HYPERTENSIVE DOGS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 260  (1) , 141-150
Abstract
The antihypertensive effect of nisoldipine (BAY K 5552 [isobutyl methyl 1,4-dihydro-2,6-dimethyl 4-(2-nitrophenyl)-3,5-pyridenecarboxylate]), a new Ca antagonist with peripheral vasodilator properties, was studied by a radiotelemetric method in conscious, unrestrained renal hypertensive dogs. Nisoldipine has a long-lasting antihypertensive action (12 h at 0.3 mg/kg p.o. [orally]) in comparison with nifedipine (6 h at 3.15 mg/kg p.o.). Its antihypertensive efficacy is equal to that of minoxidil and superior to nifedipine, hydralazine, diltiazem and verapamil. After nisoldipine, only a short-lasting initial reflex tachycardia was noted, whereas after the other vasodilators tachycardia persisted for the entire period of blood pressure reduction. Diltiazem and verapamil produced almost no tachycardia. In some cases a bradycardia was observed after high doses of verapamil.