Exploring the molecular nature of alternative oxidase regulation and catalysis
Open Access
- 11 December 2001
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 510 (3) , 121-126
- https://doi.org/10.1016/s0014-5793(01)03261-6
Abstract
Plant mitochondria contain a non‐protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water. In this paper we review theoretical and experimental studies that have contributed to our current structural and mechanistic understanding of the oxidase and to the clarification of the molecular nature of post‐translational regulatory phenomena. Furthermore, we suggest a catalytic cycle for AOX that involves at least one transient protein‐derived radical. The model is based on the reviewed information and on recent insights into the mechanisms of cytochrome c oxidase and the hydroxylase component of methane monooxygenase.Keywords
This publication has 46 references indexed in Scilit:
- Electron Flow between Photosystem II and Oxygen in Chloroplasts of Photosystem I-deficient Algae Is Mediated by a Quinol Oxidase Involved in ChlororespirationJournal of Biological Chemistry, 2000
- A motif for quinone binding sites in respiratory and photosynthetic systems 1 1Edited by R. HuberJournal of Molecular Biology, 2000
- Component Interactions in the Soluble Methane Monooxygenase System from Methylococcus capsulatus (Bath)Biochemistry, 1999
- Mutations in the Arabidopsis Gene IMMUTANS Cause a Variegated Phenotype by Inactivating a Chloroplast Terminal Oxidase Associated with Phytoene DesaturationPlant Cell, 1999
- The Reaction of the Soybean Cotyledon Mitochondrial Cyanide-resistant Oxidase with Sulfhydryl Reagents Suggests That α-Keto Acid Activation Involves the Formation of a ThiohemiacetalPublished by Elsevier ,1996
- The active site of the cyanide‐resistant oxidase from plant mitochondria contains a binuclear iron centerFEBS Letters, 1995
- Regulation of alternative oxidase kinetics by pyruvate and intermolecular disulfide bond redox status in soybean seedling mitochondriaFEBS Letters, 1994
- Organic acid activation of the alterNatlve oxidase of plant mitochondriaFEBS Letters, 1993
- Quinol oxidation in Arum maculatum mitochondria and its application to the assay, solubilisation and partial purification of the alternative oxidaseFEBS Letters, 1978
- Isolation of a cyanide‐resistant duroquinol oxidase from arum maculatum mitochondriaFEBS Letters, 1978