GAMMA–2 MSH IS NATRIURETIC IN THE RAT
- 1 March 1985
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 116 (3) , 1227-1229
- https://doi.org/10.1210/endo-116-3-1227
Abstract
Previous reports suggest that peptides containing an amino acid sequence similar to that of ACTH–(4–10) increased Na excretion in the rat. Y2MSH contains such a sequence. An in vivo rat bioassay for natriuretic factors was employed to demonstrate the natriuretic action of Y2MSH. A significant natriuretic effect was observed, with a peak response 30–50 min following the bolus injections of 0.64, 6.4 or 64 pmol, but not with smaller or larger amounts of Y2MSH. A kaliuretic and diuretic action of Y2MSH was not consistently evident. Y2MSH may represent an endogenous compound involved in the physiological regulation of Na excretion.Keywords
This publication has 0 references indexed in Scilit: