Synthesis of Base Modified Phosphorothioate Oligodeoxynucleotides as Inhibitors of HIV-1

1 January 1991

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 10 (1-3) , 555-561
https://doi.org/10.1080/07328319108046526

Abstract

Summary. By the H-phosphonate approach on a solid support we have synthesised a 28-mer homopolymer of 2′-deoxycytidine (SdC₂₈), a 28-mer phosphorothioate oligodeoxynucleotide (Srev) complementary to the HIV-1 regulatory gene and a number of its base modified derivatives. Anti HIV-1 activity of S-dC₂₈ and Srev in chronically infected T-cells was studied. Melting temperatures of rev-comp rev and Srev-comp rev were also measured.

Keywords

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