The Action of Intravenous Ethanol on Gastric Secretion

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Abstract
Summary In conscious dogs, intravenous infusion of ethanol stimulated gastric acid secretion both from the gastric fistula and from the Heidenhain pouch and stimulated pepsin secretion from the fistula but not from the pouch. Acute cervical vagal block with infiltration anesthesia had no effect on ethanol-stimulated gastric secretion. After ganglionic blockade (pentolinium tartrate) ethanol stimulated neither acid nor pepsin secretion from the fistula. Ethanol did not stimulate gastric secretion when the antrum was acidified with 0.1 N HCl. From these experiments, it was concluded that intravenous ethanol stimulated gastric secretion in the main by liberating antral gastrin.

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