On the Immunity Reactions of a Heterotransplantable Mouse Carcinoma Propagated in Rats for Seven Years

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Abstract
The following investigation was carried out with a tumour strain which can be propagated continuously in mice and in rats. The strain was sent, in 1929, to Professor de Balogh of the Pathological and Cancer Research Institute of the University in Budapest by Professor Silverstein of the Pathological Institute of the University of Vienna. It was then a transplantable mouse tumour, and was described as “Ehrlich's mouse carcinoma.” It is one of the most rapidly, if not the most rapidly, growing of transplantable tumours, and on inoculation into mice takes in 100 per cent. Histologically, it is a very cellular tumour, without any definite structure, and composed of undifferentiated round cells. After several unsuccessful attempts, I was able, in 1929, to transplant this tumour into rats, and it has been propagated continuously in rats since. Detailed accounts of these experiments have been published (Putnoky, 1930, 1933), but a brief account of the technique of transplantation and of the behaviour of the tumour in rats is necessary.

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