Noninvasive molecular imaging of small living subjects using Raman spectroscopy
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- 15 April 2008
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (15) , 5844-5849
- https://doi.org/10.1073/pnas.0710575105
Abstract
Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.Keywords
This publication has 35 references indexed in Scilit:
- Carbon nanotubes as nanomedicines: From toxicology to pharmacology☆Advanced Drug Delivery Reviews, 2006
- Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cellsGene Therapy, 2006
- A Nanoparticle-Based Model Delivery System To Guide the Rational Design of Gene Delivery to the Liver. 2. In Vitro and In Vivo Uptake ResultsBioconjugate Chemistry, 2005
- Real-time Raman system for in vivo disease diagnosisJournal of Biomedical Optics, 2005
- SERRS as a more sensitive technique for the detection of labelled oligonucleotides compared to fluorescenceThe Analyst, 2004
- Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal ModelsMolecular Imaging, 2004
- Molecular imaging in living subjects: seeing fundamental biological processes in a new lightGenes & Development, 2003
- Medical applications of Raman spectroscopy: From proof of principle to clinical implementationBiopolymers, 2002
- Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman ScatteringScience, 1997
- Imaging with Extrinsic Raman LabelsApplied Spectroscopy, 1996