A pharmacokinetic study of mianserin

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Abstract
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 µg/l at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3–2.8), (t1/2)α 2.5 h (0.9–4.7), (t1/2)β 21 h (14–33), (Vd)β 27.5 l/kg (16.8–46.5) and Cloral 0.98 l/kg/h (0.47–1.75). Blood/plasma concentration ratios ranged from 0.50–0.74.