FACTORS AFFECTING THE β-CELL SENSITIVITY TO ALLOXAN IN VIVO
- 1 July 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 88 (3) , 556-561
- https://doi.org/10.1530/acta.0.0880556
Abstract
Blood glucose and pancreatic islet morphology were studied in mice subjected to different kinds of treatment both before and after alloxan administration. d-Glucose, d-mannose, d-fructose, NaHCO3 and sodium lactate protected against alloxan when given before, but not when given after alloxan, whereas l-leucine protected when administered before, and also when injected 1 or 3 min after alloxan. No protection was seen in animals receiving l-leucine 10 min following alloxan. The findings may indicate that the mechanism for alloxan protection by 1-leucine differs from that of the other compounds tested.This publication has 0 references indexed in Scilit: