Adenosine Deaminase in the Diagnosis of Pleural Effusions
- 12 January 1984
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 215 (4) , 299-304
- https://doi.org/10.1111/j.0954-6820.1984.tb05011.x
Abstract
The activity of adenosine deaminase (ADA) was determined in serum and pleural fluid of 90 patients with pleural effusions of various etiology. Tuberculous pleural effusions, empyemas and rheumatoid pleural effusions demonstrated significantly higher activities of ADA than parapneumonic, nonspecific and malignant pleural effusions and effusions in systemic lupus erythematosus and congestive heart failure. In tuberculosis, empyema and rheumatoid arthritis ADA activity was significantly higher in pleural fluid than in serum, indicating a local synthesis of ADA by cells within the pleural cavity in these diseases.Keywords
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