Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins
Open Access
- 23 October 2009
- journal article
- Published by Springer Nature in Metabolic Brain Disease
- Vol. 24 (4) , 673-684
- https://doi.org/10.1007/s11011-009-9169-y
Abstract
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.Keywords
This publication has 36 references indexed in Scilit:
- HIF-2α, but not HIF-1α, promotes iron absorption in miceJournal of Clinical Investigation, 2009
- Iron absorption and metabolismCurrent Opinion in Gastroenterology, 2009
- Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron DeficiencyCell Metabolism, 2009
- Iron–sulfur cluster biogenesis and human diseaseTrends in Genetics, 2008
- The blood–CSF barrier explained: when development is not immaturityBioEssays, 2008
- Genome-wide atlas of gene expression in the adult mouse brainNature, 2006
- Age-Related Changes in Iron Homeostasis and Cell Death in the Cerebellum of Ceruloplasmin-Deficient MiceJournal of Neuroscience, 2006
- The Steap proteins are metalloreductasesBlood, 2006
- Iron, brain ageing and neurodegenerative disordersNature Reviews Neuroscience, 2004
- A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the ratDevelopmental Brain Research, 1990