NE1: a New Neutrophil Specific Antigen

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Abstract
The sera of 3 children with chronic benign neutropenia due to anti-neutrophil antibodies [Ab] were studied with respect to their Ab specificity. This was done by screening the sera against a panel of leukocyte donors in the EDTA micro-agglutination test and in the indirect fluorescence test. Of the sera, 2 contained Ab against the known neutrophil-specific antigen [Ag] NA2. The 3rd serum was directed against a new neutrophil-specific Ag. Genetic analysis showed no correlation between this Ag and the already known neutrophil-specific Ag: 9A, NA1, NA2, NB1 and NC1. In the Dutch population the frequency of the new Ag, tentatively called NE1, is 23%, which gives a gene frequency of 0.12.