MOTION SICKNESS

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Abstract
Evidence is presented for the following conclusions: Motion sickness is associated with pallor, cold sweating, salivation, and quiescent gastric musculature. The vomiting of motion sickness is a reflex of skeletal musculature in which the stomach plays a purely passive part. Olfactory and optic stimuli may facilitate this reflex. Motion sickness is due to stimulation of either the semicircular canals, the otolith apparatus of the utricle, or both. It can be abolished in sensitive dogs by removal of the flocculo-nodular lobe of the cerebellum, but not by decerebration. A considerable degree of adaptation to motion is acquired rapidly by most subjects. Of the many drugs tried for the relief of motion sickness the most effective is hyoscine. Atropine is slightly less useful and the barbiturates still less. Various mixtures of these drugs are usually less valuable than hyoscine alone. "Dramamine," an antihistaminic and antispasmodic, has proved a most effective remedy in severe cases. Whether it be superior hyoscine it is perhaps too early to say.

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