An Improved Synthesis of 3′,4′-Dideoxykanamycin B
- 1 April 1979
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 52 (4) , 1131-1134
- https://doi.org/10.1246/bcsj.52.1131
Abstract
A new synthetic route has been exploited for the large scale production of 3′,4′-dideoxykanamycin B starting with kanamycin B. The key stage in the synthesis involves the formation in excellent yield of the 3′,4′-anhydro-4′-epi derivative (5) followed by convertion to the 3′-ene derivative through the iodohydrin. Compound 5 was prepared by the treatment of 3′,2″-di-O-benzoyl-4″,6″-O-cyclohexylidene-4′-O-methylsulfonyl-penta-N-t-butoxycarbonyl-kanamycin B with sodium methoxide.This publication has 10 references indexed in Scilit:
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