Cornea preparation for in vitro biopharmaceutical evaluation of ophthalmic dosage forms
- 1 December 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (12) , 919-922
- https://doi.org/10.1111/j.2042-7158.1975.tb10248.x
Abstract
A system has been developed for a specific biopharmaceutical purpose: testing, for ophthalmic preparations, the influence of formulation on drug transport through the cornea. The apparatus is a lucite cell, divided in two compartments by a clamped rabbit cornea. Physiological conditions are ensured by a supply of oxygenated perfusion medium. They are monitored by electrical conductivity and corneal thickness measurements. Reliability of the system was tested in a set of experiments.Keywords
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