Studies of Unusual Amino Acids and Their Peptides. XV. The Chemistry of N-Carboxymethyl Amino Acids. III. The Synthesis of N-Tosyl-N-carboxymethyl Amino Acid Derivatives by N-Alkoxycarbonylmethylation
- 1 December 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 57 (12) , 3605-3606
- https://doi.org/10.1246/bcsj.57.3605
Abstract
The alkoxycarbonylmethylation of the amide nitrogen of N-tosyl amino acid esters with iodoacetic acid esters in the presence of silver(I) oxide in N,N-dimethylformamide afforded the corresponding N-tosyl-N-carboxymethyl amino acid esters in good yields without racemization of the amino acids.Keywords
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