Synthesis of C-2″β- and C-2″α-fluoro avermectin B1a
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 368-370
- https://doi.org/10.1039/c39870000368
Abstract
A synthesis of protected C-2β- and C-2α-fluoro oleandrosyl fluorides is presented; coupling of these carbohydrates with avermectin B1a monosaccharide 5-O-t-butyldimethylsilyl derivative, followed by deprotection, furnished the title compounds whose biological activity was evaluated.Keywords
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