Microtubule-Macrotubule Transitions: Intermediates after Exposure to the Mitotic Inhibitor Vinblastine
- 27 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4170) , 1219-1221
- https://doi.org/10.1126/science.186.4170.1219
Abstract
Vinblastine treatment of microtubule protein or intact microtubules assembled in vitro produced bifilar rings and bifilar helices. Suspentsions of rings and helices were demonstrated to bind [3H]colchicine, a diagnostic property of microtubule protein. Macrotubules are suggested to consist of tightly coiled helices formed by longitudinal compacting of loosely coiled protofilament pair intermediates.Keywords
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