Immunoglobulin M: Fixation of Human Complement by the Fc Fragment
- 7 April 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4030) , 55-56
- https://doi.org/10.1126/science.176.4030.55
Abstract
The Fc fragment [(Fc)5µ with a molecular weight of 342,000] of human immunoglobulin M from patients with Waldenström's macroglobulinemia has a complement fixing ability approximately 19 times greater on a molar basis than that of the parent immunoglobulin M. This fragment, which occurs naturally as a pentamer fixes human but not guinea pig complement, and this activity remains unchanged even after the fragment is reduced to the monomeric form.Keywords
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