Differential Response of Serum Alkaline Phosphatase and Serum Osteocalcin in Paget'S Osteosarcoma

1 March 1991

journal article
case report
Published by SAGE Publications in Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

Vol. 28 (2) , 194-195
https://doi.org/10.1177/000456329102800216

Abstract

Serum osteocalcin did not show any response to the onset of osteosarcoma in Paget's disease of bone whereas serum alkaline phosphatase increased rapidly. This suggests that osteocalcin is not useful in the diagnosis and management of Paget's osteosarcoma and does not reflect the same osteoblastic processes in bone as serum alkaline phosphatase.

Keywords

This publication has 5 references indexed in Scilit:

P2. Assessment of response to APD in Paget's disease of bone
Bone, 1989
Serum osteocalcin and other indices of bone formation: An 8-decade population study in healthy men and women
Clinica Chimica Acta; International Journal of Clinical Chemistry, 1988
An evaluation of serum osteocalcin in pacet's disease of bone and its response to diphosphonate treatment
Arthritis & Rheumatism, 1988
Clinical Evaluation of Bone Turnover by Serum Osteocalcin Measurements in a Hospital Setting*
Journal of Clinical Endocrinology & Metabolism, 1984
Two Improved and Simplified Methods for the Spectrophotometric Determination of Hydroxyproline.
Analytical Chemistry, 1963