Heparin inhibits the activity of protein phosphatase‐1

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Abstract
Heparin inhibited the dephosphorylation of rabbit skeletal muscle or liver phosphorylase a by protein phosphatase‐1. Other glycosaminoglycans (chondroitin sulfates) and their constituents were found to be without effect. The chromatography of a partially purified phosphatase preparation on heparin—Sepharose CL‐6B resulted in a fraction that did not bind to the matrix and its activity was not inhibited by heparin or inhibitor‐1. The phosphatase bound to heparin—Sepharose was eluted by 0.2 M NaCl and was inhibited by heparin or inhibitor‐1.