CHROMATOPHOROTROPIC PRINCIPLE OF THE PARS INTERMEDIA OF THE PITUITARY

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Abstract
It has long been known that the hypophysis produces an active substance which exerts an influence on the chromatophores of cold-blooded animals. When one injects an extract of the posterior lobe of the pituitary into the lymph sac of a light colored frog (one previously exposed to light rays), the color of the skin becomes dark after a very brief interval. This change in color is due to the marked expansion of the melanophores.1Swingle, as well as Allen, Atwell and Smith, elicited a darkening of the skin in both normal and hypophysectomized tadpoles, by means of implantation of posterior pituitary tissue and by placing the animals into solutions of posterior pituitary extract. The expansion of melanophores can be elicited also by placing pieces of skin which have been cut from the animal into an extract of the posterior pituitary; the differing degrees of expansion have been

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