Rabbit and ferret parietal cell inhibition byHelicobacter species

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Abstract
We tested sonicates ofHelicobacter pylori, H. mustelae, andH. felis for inhibition of acid secretion in rabbit and ferret isolated gastric glands. ThreeH. pylori strains, two of threeH. mustelae strains, and twoH. felis strains significantly inhibited acid secretion in rabbit cells by 95.2–93.3%, 55.9% and 96.4%, and 83.4–96%, respectively. AllHelicobacter strains examined inhibited acid secretion by ferret cells by 65.3–76.8%, 89.1–97.6%, and 85.8–92.8%.H. pylori inhibited acid secretion after stimulation with histamine and isobutylmethylxanthine or with 8-bromo-cyclic adenosine monophosphate (PHelicobacter species tested. It occurs independently of the mammalian origin of the parietal cell, and it does not involve blockade of histamine-2 receptors.