High‐Dose Intravenous Gammaglobulin Therapy for Neonatal Immune Haemolytic Jaundice due to Blood Group Incompatibility

Publisher Website
Google Scholar
Abstract
Three newborn infants who developed hyperbilirubinemia due to blood group incompatibility were treated with high‐dose gammaglobulin. Hyperbilirubinemia was caused by Rhesus (Rh) incompatibility (anti‐E + anti‐c) in Infant 1 and ABO incompatibility (anti‐B) in Infants 2 and 3. Hyperbilirubinemia was refractory to conventional phototherapy but responded well to intravenous gammaglobulin (IVGC) at dose of 1 g/kg in all infants. No adverse effects were observed. These findings suggest that high‐dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune baemolytic disease resistant to phototherapy.