SERUM APOLIPOPROTEINS A‐I, A‐II AND B IN DIABETIC CHILDREN AND MATCHED HEALTHY CONTROLS

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Abstract
Serum concentrations of apolipoprotein (apo) A‐I, A‐II and B were determined in 28 diabetic children (age 3–16 years) and 14 healthy matched controls. In the healthy children the serum apo A‐I concentration was 120 ± 20 arbitrary units (A. U.) (mean ± S. D.), apo A‐II 111 ± 14 A. U. and apo B 100 ± 34 A. U. (100 A. U. =mean concentration in adult blood donors). The apo A‐I concentration was significantly higher in the diabetic children (134 ± 13; p <0.02) than in the healthy controls. In diabetics apo A‐II was 116 ± 14 A. U. and apo B 106 ± 21 A. U., values not significantly different from those in the controls. The serum cholesterol concentration in the healthy children correlated strongly to apo A‐I and apo A‐II, which was not the case in the diabetics. The differences between diabetic and healthy children with respect to correlations between the apolipoproteins and the serum lipids might indicate a different apolipoprotein/lipoprotein lipid relationship in diabetics.