Enhancement of the Susceptibility of Staphylococcus aureus to Phagocytosis after Treatment with Fosfomycin Compared with Other Antimicrobial Agents
- 1 January 1995
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 41 (1) , 45-49
- https://doi.org/10.1159/000239323
Abstract
Phagocytosis and intracellular killing of invading pathogens by host cells play the major role in resistance to bacterial infections. In vitro, antibiotics improve the susceptibility of microorganisms to antimicrobial activity of leukocytes, suggesting that this effect may contribute to determine the antimicrobial therapy and safe dosing intervals. The susceptibility of Staphylococcus aureus to phagocytosis and killing by human polymorphonuclear leukocytes (PMNL) in the presence of normal human serum in the postantibiotic phase of fosfomycin were compared with ciprofloxacin, cefotaxime and pristinamycin. Pretreatment of S. aureus for 10 min with 4 × MIC of fosfomycin and ciprofloxacin clearly sensitized the bacteria to leukocytic killing in the presence of normal human serum (10% v/v); cefotaxime and pristinamycin failed to enhance the phagocytic killing.Keywords
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