REGULATION OF INTRACELLULAR CYCLIC-GMP AND CYCLIC-AMP LEVELS IN MOUSE LUNG FRAGMENTS BY DISODIUM-CROMOGLYCATE, BETA-ADRENERGIC AGONISTS, CHOLINERGIC ACTIVATORS, AND HISTAMINE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 17  (4) , 639-647
Abstract
The effects of adrenergic and cholinergic agents and disodium cromoglycate (DSCG) on the levels of cyclic[c]AMP and cGMP in mouse lung fragments were studied. Levels of cAMP were enhanced by 2 of the known .beta.-adrenergic agonists, epinephrine and isoproterenol. This increase was abolished by propranolol, a recognized .beta.-adrenergic antagonist. DSCG, a proposed inhibitor of phosphodiesterases, alone caused a slight, significant increase in cAMP. In the presence of epinephrine, levels of cAMP were potentiated by DSCG. DSCG behaved as a typical cAMP phosphodiesterase inhibitor. cGMP levels were increased by carbachol, acetylcholine and the phosphodiesterase inhibitor, aminophylline, but not by DSCG or .beta.-adrenergic agonists.

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