Necic acid synthons. Part 4. Regioselectivity in the reactions of chloro and lodo derivatives of selected 3-hydroxy-2-methylenealkanoate esters with ethyl 2-methyl-3-oxobutanoate
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1143-1145
- https://doi.org/10.1039/p19850001143
Abstract
Iodination of 3-hydroxy-2-methylenealkanoate esters with HI-H3PO4 proceeds with exclusive rearrangement, whereas in some cases, chlorination with hexachloroacetone–triphenylphosphine affords both normal and rearranged products. Substituent and solvent effects on the regioselectivity of nucleophilic displacement in these halogeno derivatives are discussed.Keywords
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