UPTAKE AND METABOLISM OF [1,2-3H]PROGESTERONE INJECTED INTRALUMINALLY INTO THE UTERI OF SPAYED MICE

1 September 1973

journal article
Published by Bioscientifica in Journal of Endocrinology

Vol. 58 (3) , 555-562
https://doi.org/10.1677/joe.0.0580555

Abstract

[1,2-³H]Progesterone (5–50 pg) injected intraluminally into the uterus of spayed mice was retained only to a small extent; producing a 'half-life' of about 30 min compared with > 240 min for [6,7-³H]oestradiol-17β (50 pg). Retention of progesterone by the uterus was not significantly different from that by the plantaris muscle, a non-target tissue. Paper chromatography of extracts indicated that metabolism of [1,2-³H]progesterone occurred in both the uterus and the vagina within 5 min of local injection. There was more metabolism in the vagina and it was qualitatively different. No selective retention of progesterone or its metabolites occurred in either organ. The proportion of the radioactivity present as progesterone over 120 min after injection remained constant.

Keywords

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