Frequency of the ΔF508 mutation on cystic fibrosis chromosomes in Denmark
- 1 September 1990
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 85 (4) , 427-428
- https://doi.org/10.1007/bf02428297
Abstract
We have investigated the frequency of the ΔF508 mutation on cystic fibrosis (CF) chromosomes in Denmark. Of 304 chromosome tested, 86.8% have the ΔF508 mutation. The majority of the chromosomes with this mutation are found on chromosomes with the XV2c/KM19 haplotype B (97.3%), whereas 15/16 chromosomes with haplotype C have another mutation, confirming that only very few mutations will account for the majority of CF genes in the Danish population.Keywords
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