Anti‐IL‐10 Treatment Does Not Block Either the Induction or the Maintenance of Orally Induced Tolerance to Ova
- 1 April 1995
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 41 (4) , 319-323
- https://doi.org/10.1111/j.1365-3083.1995.tb03573.x
Abstract
Herein, the role of IL-10 in the induction and maintenance of oral tolerance was evaluated. The results show that: (1) mice treated with MoAb anti-IL-10 are permissive to the induction of oral tolerance to OVA; (2) anti-IL-10 treatment did not reverse the in vitro blocking of T cell proliferative response found in orally-tolerized mice; and (3) orally-induced tolerance could not be broken by anti-IL-10 treatment. Taken together, these results suggest that IL-10 is not a fundamental cytokine for the establishment and maintenance of oral tolerance.Keywords
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