Exercise and human collateralization: an angiographic and scintigraphic assessment.

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Abstract
The effect of exercise on the development of intercoronary collaterals and on left ventricular function was studied. Male patients (mean age 48 yr, range 36-54 yr) who had suffered acute myocardial infarction were randomly assigned to an exercise group (10 patients) and a control group (10 patients). Both groups underwent coronary angiography, left ventricular function studies and myocardial perfusion studies with labeled microspheres, before and after the 7 mo. experimental period. Both groups had similar extent of disease as measured angiographically and both had mild progression of disease. Neither group showed changes in extent of collateralization, myocardial perfusion or left ventricular function. The exercise group had a significant increase in anginal threshold and a significant (P < 0.01) decrease in heart rate at a given work load. Exercise, does not appear to affect progression of disease, myocardial perfusion, extent of collateralization or left ventricular function in patients with coronary artery disease.

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