Endothelial Cell Ischemic Injury: Protective Effect of Heparin or Aspirin Assessed by Scanning Electron Microscopy

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Abstract
Scanning electron microscopic observations of the luminal surface of the rabbit common carotid artery subjected to occlusion for 30 minutes or two hours revealed crater-like and balloon-like defects in the endothelial surface. The frequency of occurrence of these abnormalities was significantly decreased by pretreatment with heparin or aspirin in doses considered to have antiplatelet aggregating activity.

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