Comparison of alphafetoprotein and β‐ trace protein in the antenatal diagnosis of anencephaly and spina bifida

23 April 1976

journal article
research article
Published by Wiley in Clinical Genetics

Vol. 9 (4) , 385-388
https://doi.org/10.1111/j.1399-0004.1976.tb02267.x

Abstract

Alpha-fetoprotein (AFP) and .beta.-trace protein (BTP) concentrations were measured in amniotic fluids taken from 19 pregnancies where the outcome was an infant with a neural tube defect and from 19 matched controls. There was no significant difference in the mean BTP values for the pathological samples when compared with the controls, and there were no striking differences in the values within individual matched pairs. On the other hand, the mean AFP concentration in the abnormal amniotic fluids was approximately 15 times the mean value found in the controls. Differences within individual pairs were particularly noticeable early in pregnancy. BTP is apparently of no use for the early antenatal diagnosis of anencephaly and spina bifida.

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