Mucosal Epithelial Cells and Langerhans Cells are Targets for Infection by the Immunosuppressive Type D Retrovirus Simian AIDS Retrovirus Serotype 1

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Abstract
Simian acquired immune deficiency syndrome (SAIDS) caused by the type D retrovirus SRV-1 results in opportunistic infections and a spectrum of oral lesions similar to those seen in humans with AIDS. To better understand the pathogenesis of these oral lesions we have retrospectively examined the oral mucosa from ten rhesus monkeys that died with SAIDS and prospectively examined the oral mucosa of ten additional animals inoculated with SRV-1 to determine at what time, and in what cells SRV-1 infection of the oral mucosa occurs. Using single and double label immunohistologic techniques, and electron microscopy we detected SRV-1 in clusters of oral epithelial cells and rare Langerhans cells as early as 1 month postinoculation.
Funding Information
  • U.S. Public Health Service (RR00169, PO1 DE07946, RO1‐AI20573)
  • University of California
  • U.S. Public Health Service (RR00039)
  • Sundhed og Sygdom, Det Frie Forskningsråd (12‐7499)
  • Knud Højgaards Fond
  • AIDS Fondet