The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
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- 17 July 2000
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 2 (8) , 531-539
- https://doi.org/10.1038/35019573
Abstract
PAR (partitioning-defective) proteins, which were first identified in the nematode Caenorhabditis elegans, are essential for asymmetric cell division and polarized growth, whereas Cdc42 mediates establishment of cell polarity. Here we describe an unexpected link between these two systems. We have identified a family of mammalian Par6 proteins that are similar to the C. elegans PDZ-domain protein PAR-6. Par6 forms a complex with Cdc42–GTP, with a human homologue of the multi-PDZ protein PAR-3 and with the regulatory domains of atypical protein kinase C (PKC) proteins. This assembly is implicated in the formation of normal tight junctions at epithelial cell–cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3.Keywords
This publication has 38 references indexed in Scilit:
- Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cellsNature Cell Biology, 1999
- Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell MovementThe Journal of cell biology, 1999
- ROLE OF SMALL G PROTEINS IN YEAST CELL POLARIZATION AND WALL BIOSYNTHESISAnnual Review of Biochemistry, 1998
- Rho GTPases and signaling networksGenes & Development, 1997
- Cell polarity: Par for the polar courseCurrent Biology, 1997
- Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila.The Journal of cell biology, 1996
- Protein–protein interactions: PDZ domain networksCurrent Biology, 1996
- The Caenorhabditis elegans p21-activated Kinase (CePAK) Colocalizes with CeRac1 and CDC42Ce at Hypodermal Cell Boundaries during Embryo ElongationJournal of Biological Chemistry, 1996
- A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPasesJournal of Biological Chemistry, 1995
- Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryosCell, 1995