Hyperbaric Oxygen and Acetazolamide Improve Visual Acuity in Patients With Cystoid Macular Edema by Different Mechanisms

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Abstract
Although both hyperbaric oxygen1 and acetazolamide2,3 can be used to treat chronic cystoid macular edema (CME) of variable causes, the mechanism of visual improvement remains obscure. For example, the fluorescein angiographic finding does not always correlate with the visual acuity.1-3 Two patients with chronic CME were treated by both methods. Report of Cases. Case 1. A 50-year-old man developed CME following central retinal vein occlusion in the right eye. Three months after the onset, panretinal photocoagulation was performed that was not effective in treating the CME. Since the visual acuity gradually decreased to 0.1 OD, the patient was given hyperbaric oxygen at 2 atm absolute (1 atm over the normal level) for 60 minutes and 3 atm absolute (2 atm over the normal level) for 60 minutes twice a day for 25 days. The visual acuity improved rapidly to 0.3 on day 2, to 0.5 on day

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