Induction of the Intermediate Pituitary by Stress: Synthesis and Release of a Nonopioid Form of β-Endorphin
- 25 January 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 227 (4685) , 424-426
- https://doi.org/10.1126/science.3155575
Abstract
Beta-Endorphin in the intermediate lobe of the pituitary gland is posttranslationally modified to produce opioid inactive peptides. Whether these are metabolites or biologically relevant products has not been known. It was found that repeated stress induces increased biosynthesis and release of beta-endorphin-like substances from the intermediate lobe of rats and that opioid-inactive N-acetylated beta-endorphin-(1-31) is selectively made and liberated. The possible role of this nonopioid product and the selective release of peptide forms are discussed.This publication has 17 references indexed in Scilit:
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