Changes in Left Ventricular Diastolic Function 6 Months After Nonsurgical Septal Reduction Therapy for Hypertrophic Obstructive Cardiomyopathy

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Abstract
Background —Nonsurgical septal reduction therapy (NSRT) decreases left ventricular outflow tract (LVOT) gradient and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). NSRT effects on LV/left ventricular diastolic function are currently unknown. Methods and Results —HOCM patients (n=29) had Doppler echocardiography at baseline and 6 months after NSRT to evaluate changes in LV volume, pre–A-wave pressure, early diastolic mitral annulus velocity (Ea) by tissue Doppler, and τ. At 6 months, a significant reduction in LVOT gradient (from 53.6±15 to 6±5 mm Hg; P P =0.04) and New York Health Association class (from III to I; P P P P P Conclusions —NSRT improves LV relaxation and compliance, which contributes to the symptomatic relief seen at 6 months.