Cell nuclei generate DNA‐nicking Superoxide radicals
- 6 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 194 (2) , 317-321
- https://doi.org/10.1016/0014-5793(86)80109-0
Abstract
Rat liver nuclei generate Superoxide radicals in the presence of NADPH. Active oxygen species induced nicks in nuclear DNA. This was prevented by Superoxide dismutase and catalase as well as by anaerobiosis. EDTA-Fe3+ dramatically increased the active oxygen-dependent DNA nicking.Keywords
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