The Effect of Oral Contraceptive Steroids on the Response of Thyroid-Stimulating Hormone to Thyrotropin-Releasing Hormone

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Abstract
The mean maximal TSH response to 100 μ of TRH in 15 euthyroid women was 19 ± 2.5 μ per ml (mean ± sem) compared to a mean response of 30 ± 2.5 μU per ml in 14 euthyroid patients receiving oral contraceptive steroids (P < 0.02). The results indicate that women receiving oral contraceptives have an augmented TSH response to TRH.