The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2
- 1 August 1991
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 21 (8) , 1967-1970
- https://doi.org/10.1002/eji.1830210828
Abstract
An early biochemical event associated with T cell activation is tyrosine phosphorylation. We have previously shown that p56lck, a lymphocyte‐specific protein tyrosine kinase, is hyperphosphorylated on serine and tyrosine residues 15 minutes after activation via CD2 with a concomitant shift to a higher molecular mass. We now demonstrate that the tyrosine kinase activity of p56lck is increased within seconds following CD2 triggering. This activity decreases thereafter correlating with the appearance of changes in phosphorylation previously described. These results suggest that p56lck may play an important role in the CD2 activation pathway.Keywords
This publication has 41 references indexed in Scilit:
- The retarded electrophoretic migration of p56lck induced by vanadate in lymphoma cells correlates with modified kinase activityBiochimie, 1990
- An activating combination of CD2 antibodies stimulates tyrosine phosphorylation in a T lymphocyte cell lineFEBS Letters, 1990
- Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lckNature, 1989
- The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckCell, 1988
- Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.The Journal of Experimental Medicine, 1988
- The amino terminal region of the p56 lck from LSTRA exerts negative modulation on the tyrosine kinase activityBiochemical and Biophysical Research Communications, 1987
- Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphatesEuropean Journal of Immunology, 1987
- A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRACell, 1985
- Stimulation of tyrosine phosphorylation in lectin treated human lymphocytesBiochemical and Biophysical Research Communications, 1984
- Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complexCell, 1982