Stress-induced oligomerization and chromosomal relocalization of heat-shock factor
- 31 October 1991
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 353 (6347) , 822-827
- https://doi.org/10.1038/353822a0
Abstract
The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a represser of normal gene activity during heat stress.Keywords
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