Mode of Extension of Contrast Substances Injected into Peripheral Nerves

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Abstract
The authors demonstrated visually the intraneurial tissue planes, by both radiographic and microscopic means, after the injn. of tinted radiopaque media under measured pressure. The injns. were made into the fasciculi of peripheral nerves and into the lumbar subarachnoid space. The media were found to flow readily in the nerves within the fasciculi, lateral diffusion being limited by endoneurial connective tissue planes; they lay discretely localized in the periaxonal connective tissue of the fasciculi in the distal portions of the nerves. Near the dura mater, the media were in the perineurial interstices and finally in the perineurium itself. If the material was injd. peripherally, it entered the subdural space and broke through into the subarachnoid space at or near the arachnoid space; if it was injd. into the subarachnoid space it entered the same perineurial areas but did so only under excessive pressures. The evidence suggests that the perineurial spaces are simply tissue spaces in the connective tissue stroma of the nerves.

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