Absence of Effect of Propoxyphene on Antipyrine Kinetics in the Rabbit
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 27 (4) , 241-244
- https://doi.org/10.1159/000137877
Abstract
The effect of propoxyphene on the elimination kinetics of antipyrine was examined in New Zealand white rabbits. Serum concentrations of antipyrine were measured by high-performance liquid chromatography (HPLC). No significant alterations in the elimination half-life, apparent volume of distribution or total plasma clearance of antipyrine were observed with propoxyphene pretreatment. These results are in contrast to the reported impaired clearance of antipyrine by propoxyphene in man.Keywords
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