Protein expression of the α, γ, δ and ε subspecies of protein kinase C changes as C6 glioma cells become contact inhibited and quiescent in the presence of serum

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Abstract
Total protein kinase C (PKC) activity and protein expression of the α and δ subspecies of PKC increases markedly as C6 glioma cells grow from low cell density to the contact-inhibited quiescent state (also known as G0) in the presence of serum. At the same time protein expression of PKC subspecies γ and ϵ decreases while the β I, β II, ι and ζ subspecies did not change. Serum deprivation of growing C6 glioma cells does not induce the same changes in PKC subspecies protein expression. The findings support the growing view that there are significant differences between the G0 states brought about by contact inhibition or serum deprivation.