PROSTACYCLIN (PROSTAGLANDIN-I2, PROSTAGLANDIN-PGI2 INHIBITS PLATELET-ADHESION AND THROMBUS FORMATION ON SUBENDOTHELIUM
- 1 January 1979
- journal article
- research article
- Vol. 53 (2) , 244-250
Abstract
Prostaglandin I2 (prostacyclin, PGI2), a substance synthesized in the blood vessel wall inhibits platelet aggregation in stirred platelet-rich plasma. Segments of deendothelialized rabbit aorta were perfused at arterial shear rates with human blood and platelet adhesion and thrombus formation on subendothelium were inhibited in blood containing 10 nM PGI2. PGI2 appears to reduce adhesion by inhibiting platelet spreading. PGI2 could possibly regulate the platelet deposition on vascular surfaces.This publication has 12 references indexed in Scilit:
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