Haemoglobin adducts as biomarkers of exposure to the herbicides propanil and fluometuron
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Biomarkers
- Vol. 1 (2) , 136-140
- https://doi.org/10.3109/13547509609088681
Abstract
Aromatic amine herbicides, including propanil, fluometuron, alachlor, trifluralin, and pendimethalin, were examined for their ability to form haemoglobin adducts in rats as potential biomarkers of exposure. Many aromatic amines are known to form haemoglobin adducts via conversion to the nitroso metabolite and binding of this metabolite to cysteinyl groups on haemoglobin. Since red blood cells are long lived, adducts formed with these cells may be reliable biomarkers of exposure with the potential for showing progressive accumulation. Gas chromatographic-mass spectrometric analyses of haemoglobin revealed that adducts were formed in rats treated with the rice herbicide propanil and the cotton herbicide fluometuron. Adducts were not detected with the herbicides alachlor, trifluralin, or pendamethalin.Keywords
This publication has 15 references indexed in Scilit:
- Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on ProteinsAnnual Review of Pharmacology and Toxicology, 1992
- Propanil-induced methemoglobinemia and hemoglobin binding in the ratToxicology and Applied Pharmacology, 1990
- Metabolism of the arylamide herbicide propanilToxicology and Applied Pharmacology, 1990
- Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.Proceedings of the National Academy of Sciences, 1988
- Cancer Risk of Pesticides in Agricultural WorkersPublished by American Medical Association (AMA) ,1988
- Biomonitoring of aromatic amines II: hemoglobin binding of some monocyclic aromatic aminesArchives of Toxicology, 1988
- DNA adduct formation by alachlor metabolitesLife Sciences, 1988
- Erythrocyte protein conjugates as a principle of biological monitoring for pesticidesToxicology Letters, 1986
- Biomonitoring of aniline and nitrobenzeneArchives of Toxicology, 1985
- Metabolism of trifluralin in the rat and dogToxicology and Applied Pharmacology, 1966