Complementation of two mutant p53: Implications for loss of heterozygosity in cancer
- 17 March 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (10) , 2231-2235
- https://doi.org/10.1016/j.febslet.2005.03.012
Abstract
Remarkably, a cancer cell rarely possesses two mutant p53 proteins. Instead, mutation of one allele is usually associated with loss of the second p53 allele. Why do not two mutant p53 co-exist? We hypothesize that two different p53 may complement each other, when expressed at equal levels. By titrating trans-deficient and DNA-binding-deficient p53 in cells with mutant p53 and by co-transfecting distinct mutant p53 in p53-null cells, we demonstrated activation of p53-dependent transcription. We suggest that, due to complementation of two mutant p53, cancer cells need to delete the second p53 allele rather than mutate itKeywords
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