Side reaction in peptide synthesis
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 35 (1) , 52-54
- https://doi.org/10.1111/j.1399-3011.1990.tb00720.x
Abstract
2-Oxazolidone derivatives formed through an intramolecular reaction in the process of alkaline treatment of urethane-type N-protected peptides of which the N-terminal residues were Ser or Thr having unprotected hydroxyl groups. In order to avoid this side reaction, the esters of these peptides could be cleaved by enzymatic hydrolyses instead of saponification.Keywords
This publication has 4 references indexed in Scilit:
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